It is safe to take PACs and D-Mannose together. However, we suggest taking each ingredient separately as some preliminary research shows that D-Mannose may lower the effectiveness of PACs when taken at the same time.
Our recommendation is the PACs to be taken at the same time daily; preferably at night so that the PACs can sit in your bladder longer (while you sleep). D-Mannose can be taken during the day.
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